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Technical Report Documentation Page

1. Report No.

DOT HS 810 558

2. Government Accession No.

3. Recipient’s Catalog No.

4. Title and Subtitle

Literature Review of Polypharmacy and Older Drivers: Identifying Strategies to Collect Drug Usage and Driving Functioning Among Older Drivers

5. Report Date

February 2006

6. Performing Organization Code

7. Author(s)
Kathy H. Lococo and Loren Staplin, Ph.D.

8. Performing Organization Report No.

9. Performing Organization Name and Address

TransAnalytics, LLC
1722 Sumneytown Pike, Box 328
Kulpsville , PA 19443

10. Work Unit No. (TRAIS)

11. Contract or Grant No.

DTNH22-02-D-85121
Task Order No. 0004

12. Sponsoring Agency Name and Address

National Highway Traffic Safety Administration
Office of Research and Technology
400 Seventh Street, S.W.
Washington, DC 20590

13. Type of Report and Period Covered

Task Report

14. Sponsoring Agency Code

15. Supplementary Notes

COTR: Dr. Suzanne Feldman, NTI-132

16. Abstract

This research product updates the state-of-the-knowledge regarding key factors that bear on NHTSA’s ability to investigate the effects of multiple medications on safe driving among older people. First, the prevalence of medication use by older people in the population, the physiological/metabolic effects of specific drugs and drug classes, and the known effects on driving ability—principally for single substances—are reviewed. Next, the strengths and weakness of various methods that may be used to learn which prescription and over-the-counter drugs are being taken by older adults are described and contrasted; a consideration of which factors most strongly affect compliance with a medication regime, and which factors influence older people’ willingness to participate in studies aimed at obtaining such information, complements this discussion. The remaining section in this review examines on-road, closed course, and simulation methods that have been applied in this arena, highlighting those that appear to hold the greatest promise for evaluating the effects of drugs on driving performance while also acknowledging shortcomings and limitations that have been reported in the literature. For the most part, this review concentrates on recent (since 2001) studies accessed through print and electronic media. A bibliography containing over 200 citations is included, plus an appendix identifying potentially inappropriate medications commonly prescribed for older, community-dwelling individuals.

17. Key Words

Polypharmacy, prescription drugs, over-the-counter drugs, community-dwelling elderly, medication review, medication compliance, medication adherence, driver impairing medications, inappropriate prescribing, potentially inappropriate prescription, pharmacy administrative claims database, driver performance measurement, motor vehicle crashes, falls

18. Distribution Statement

No restrictions.

This document is available to the public through the National Technical Information Service, Springfield, VA 22161.

19. Security Classif. (Of this report)
Unclassified

20. Security Classif. (Of this page)
Unclassified

21. No. of Pages
104

22. Price

Form DOT F 1700.7 (8-72)                             Reproduction of completed page authorized
 

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