Drugs and Human Performance Fact Sheets
Cars on HighwayCars on Highway


Technical Report Documentation Page



Carisoprodol (and Meprobamate)





Gamma-Hydroxybutyrate (GHB, GBL, and 1,4-BD)


Lysergic acid diethylamide (LSD)


Methamphetamine (and Amphetamine)

Methylenedioxymethamphetamine (MDMA, Ecstasy)

Morphine (and Heroin)

Phencyclidine (PCP)


Zolpidem (and Zaleplon, Zopiclone)

Biographical Sketches of Lead Authors and Main Contributors

Technical Report Documentation Page

1. Report No.

2. Government Accession No.

3. Recipient's Catalog No.

4. Title and Subtitle

Drugs and Human Performance Fact Sheets

5. Report Date

6. Performing Organization Code

7. Author(s)

COUPER, Fiona J. and LOGAN, Barry K

8. Performing Organization Report No.

9. Performing Organization Name and Address

Washington State PatrolForensic Laboratory Services Bureau
2203 Airport Way S., Seattle, WA 98134

10. Work Unit No. (TRAIS)

11. Contract or Grant No.

12. Sponsoring Agency Name and Address’

National Highway Traffic Safety Administration
400 Seventh St., SW.
Washington, DC 20590

13. Type of Report and Period Covered

Final Report;
August 2000-March 2004

14. Sponsoring Agency Code

15. Supplementary Notes

The following toxicologists made significant contributions to both the drafting and review of the Fact Sheets: Michael Corbett Ph.D., Laurel Farrell MS., Marilyn Huestis Ph.D., Wayne Jeffrey MS, and Jan Raemakers, Ph.D. James F.Frank Ph.D. served as the NHTSA Contracting Officer's Technical Representative.

16. Abstract

A panel of international experts on drug-impaired driving met in Seattle during August 2000 to review developments in the field of drugs and human performance over the last 10 years; to identify the specific effects that both illicit and prescription drugs have on driving; and to develop guidance for others when dealing with drug-impaired driving problems. Delegates represented the fields of psychopharmacology, behavioral psychology, drug chemistry, forensic toxicology, medicine, and law enforcement experts trained in the recognition of drug effects on drivers in the field.

These Fact Sheets represent the conclusions of the Panel and include the state of current scientific knowledge in the area of drugs and human performance for the 16 drugs selected for evaluation. The selected drugs include over-the-counter medications such as dextromethorphan and diphenhydramine; prescription medications such as carisoprodol, diazepam and zolpidem; and abused and/or illegal drugs such as cocaine, GHB, ketamine, LSD, marijuana, methadone, methamphetamine, MDMA, morphine, PCP and toluene.

Keyword continuation: illicit and licit drugs and traffic safety, drugs and driving, drug-impaired driving.

17. Key Words

Carisoprodol, cocaine, dextromethorphan, diazepam, diphenhydramine, GHB,ketamine, LSD, marijuana,methadone, methamphetamine,MDMA, morphine, PCP, toluene, zolpidem,

18. Distribution Statement

19. Security Classif. (of this report)


20. Security Classif. (of this page)


21. No. of Pages


22. Price